![]() That’s why researchers continue to look for alternative treatments. They’re not always effective: Only a third of people improve on the first antidepressant they take less than two-thirds of people get better after trying four antidepressants. They’re slow - taking four to six weeks to kick in. Drugs that target serotonin, however, don’t work very well. That’s why doctors prescribe SSRIs - selective serotonin reuptake inhibitors - to increase serotonin. When these neurotransmitter levels fall, we get depressed. You’ve probably heard bits and pieces about how depression works: In short, neurotransmitters such as serotonin and dopamine play central roles in mood. In doing so, these drugs are challenging traditional ideas of how we understand and treat depression. Precisely how they work on the brain, however, strays wildly from prescription antidepressants. ![]() Everything from shrooms and weed to molly and ketamine - once known mainly as party drugs - is finding a place in clinical trials for depression and other mental health conditions.
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